Head of Analytical Development (m/f/d)

Pieris Pharmaceuticals (Nasdaq: PIRS) is a clinical-stage biotechnology company with operations in Germany and the United States. Pieris discovers and develops Anticalin^® protein-based drugs to target validated disease pathways in a unique and transformative way. Our pipeline includes inhalable Anticalin proteins to treat respiratory diseases and immuno-oncology multi-specifics tailored for the tumor microenvironment. Proprietary to Pieris, Anticalin proteins are a novel class of therapeutics validated in the clinic and by partnerships with leading pharmaceutical companies. It is our mission to develop life-changing therapeutic proteins for patients suffering from cancer and respiratory diseases through the innovative application of novel science and cutting-edge technologies.

The new Head of Analytical Development will report to the Head of Technical Development, and will oversee internal and external CMC analytics. As an enthusiastic and self-motivated scientist and a leader, you will be involved in the state-of-the-art discovery and development of highly novel therapeutic proteins based on Pieris’ proprietary Anticalin^® technology.
 

• Leading Pieris’ internal Analytical Development (AD) team responsible for:
  • Protein characterization with multiple spectrophotometric (UV/Vis), chromatography (SEC, IEX, RP), capillary (cSDS, IEF) and related methods (DSF, DSC) etc.
  • Performing a multi-stage “Developability” assessment of different Anticalin-based therapeutic^® formats
  • Analytical method development and optimization
• Planning and overseeing execution of outsourced analytical work (roughly equivalent to the internal workload) and establishing such partnerships as ‘external workbench’.
• Team management (goal setting, performance review, personal development etc.)
• Data interpretation and presentation (internal and external data)
• Coordination of different project-related activities within the team, associated teams (DSP, Formulation development and QC), collaboration partners as well as with multiple CRO/C(D)MOs
• Transfer of scientific data and processes from/to CRO/C(D)MOs and collaboration partners (e.g. preparation of protocols, participation in telephone conferences, scientific guidance)
• Authoring and review of technical documents as well as preparation and review regulatory documents in sections related to AD
• Identification, mitigation and if necessary, escalation of project risks (quality, timeline, budget, scope) to appropriate stakeholders and management menbers

• PhD or equivalent degree in Biotechnology, Immunology, Biochemistry, Biochemical Engineering, or related scientific area
• 3+ years of industrial experience in drug discovery and development with a focus on protein characterization; experience with multi-specific formats is a plus
• Experienced in leading teams
• Strong scientific, technical and “hands-on” background in protein analytics (HPLC, gel and capillary techniques, DSF/DSC, stability assessment etc.), mass spectrometry analysis of biomolecules and data interpretation is a plus
• Expertise in other relevant areas such as protein sequence analysis (including public database sources), protein modeling, mAb developability assessment, accelerated stability, CD spectrometry, X-ray crystallography, DLS etc. is a plus
• Experience in multivariate data analysis is a plus
• Familiarity with standard computer software, including MS Office package and other specialized software (Chromeleon, Geneious, Prism Graphpad etc.)
• Well-organized, team-oriented and used to work in an independ and efficient ways
• Self-motivated and ready to take on responsibility for their own work as well as for their team
• Advanced communication skills in English expected

Pieris is a fast-growing biotechnology company with approximately 130 employees across our sites in Munich, Germany and Boston, United States. We work in flat hierarchies with short decision-making paths and offer a working environment characterized by cooperation and innovation. Each of our employees participates in a bonus program based on the achievement of our company goals. In addition, we offer each employee the opportunity to participate in a stock purchase plan as well as a stock option program that allows Pieris employees to benefit directly from the our success.
 
Numerous social benefits such as an additional employer-financed company health insurance, free drinks etc. as well as a bright, friendly and ultra-modern working environment with excellent technical equipment in both of our locations round off our overall package. Creative employee events take place several times a year, as we believe that a healthy spirit of collaboration is key to our success.
 

Zeppelinstraße 3
85399 Hallbergmoos
+49 (0) 811 - 12447 0